Core competencies in the microbiological synthesis of the continuous-flow mode of C2, C3 and C4 chemicals, the raw materials of which may include various carbohydrate sources (starches of cereals and vegetables, waste products of sugar and food industry, as well as potential raw materials – cellulose and hemicellulose). As of end products, long-term experience in the field of the production of ethanol, lactic acid as well as butyric acid, fumaric acid, and malonic acid is identified.